Endocrine Abstracts

Introduction: Obesity related glomerulopathy (ORG) is an emerging epidemic alongside increasing incidences of obesity. ORG pathophysiology has not been explored despite poor prognosis in untreated patients. MCP-1, MIF, CCL-18 and CCL-15 are novel cytokines that may be pathologically involved in obesity-induced renal injury and explored in this study.Methods: Blood pressure, urine and blood samples were collected from 34 morbidly obese patients before and...

Background: Roux-en-Y Gastric Bypass (RYGB) results in sustained weight loss. Changes in food preferences and eating behaviour are postulated as possible contributing mechanisms. Post-RYGB, patients consume less sugary and fatty food. Sweet taste detection and sensitivity have been reported to be enhanced post-surgery and this may account for changes in the palatability of food. Underlying mechanisms for the changes in sweet taste function and eating behaviour are unclear....

Objective: Bariatric surgery is currently the most effective treatment for weight loss and diabetes remission. There are conflicting reports in the literature regarding the glucagon levels after RYGB surgery, likely due to cross-reactivity with oxyntomodulin and glicentin. The aim of this study was to characterize the proglucagon peptide family responses post-RYGB surgery in obese patients with type 2 diabetes using validated assays.Method: Nineteen obes...